Biochem/physiol Actions
Target IC50: 670 nM against telomerase activity in TRAP lysate prepared from U937 cells
Reversible: yes
Product does not compete with ATP.
Primary TargetTRAP lysate prepared from U937 cells
Cell permeable: yes
General description
A cell-permeable, bis-catechol containing, m-phenylenediamide compound that displays anti-proliferative properties. Acts as a potent, reversible inhibitor of telomerase activity (IC50 = 670 nM, TRAP lysate prepared from U937 cells). Prolonged treatment with MST-312 has been reported to result in telomere shortening and growth arrest in U937 cells. Does not inhibit the activity of Taq DNA polymerase (IC50 >3 µM).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Seimiya, H., et al. 2005. Cancer Cell7, 25.Seimiya, H., et al. 2002. Mol. Cancer Ther.1, 657.
Packaging
Packaged under inert gas
10 mg in Plastic ampoule
Reconstitution
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: